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Retatrutide’s TRIUMPH-1 discontinuation rate (11.3% at 12 mg) ran meaningfully higher than tirzepatide’s (~6.2%) or semaglutide’s (~7.3%), which is exactly the kind of mechanism-specific tolerability question that only becomes visible once you’re studying more than one compound side by side

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172 PROM2 regulates endocytosis, and its overexpression leads to significant changes in plasma membrane organization and function, including increased cellular pseudopodia, which has invasive potential and is a potential biomarker for predicting distant metastasis and decreased survival