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Non-canonical GH-GHR intracellular signaling is typically independent of JAK2, and involves recruitment of Src family non-receptor tyrosine kinases (45), stimulation of phospholipase Cγ (PLCγ) and via cytosolic calcium flux from organelles, activation of protein kinase C (PKC) (47)

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It is naturally produced by the body, but levels may vary due to lifestyle, environmental exposure, and metabolic demands